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Epieriocalyxin A

CAS No. 191545-24-1

Epieriocalyxin A( —— )

Catalog No. M29299 CAS No. 191545-24-1

Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Epieriocalyxin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
  • Description
    Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.(In Vitro):Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. EpiA induced annexin V flipping in the cell membrane and DNA fragment. We also showed that EpiA induced the generation of ROS in cells, as well as damage of the mitochondrial membrane. Western blot results showed that both JNK and ERK1/2 activation was decreased after EpiA treatment in a dose-dependent manner. EpiA increased the expression of caspase 3 and Bax and decreased Bcl2 expression.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    PERK
  • Recptor
    ERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    191545-24-1
  • Formula Weight
    344.4
  • Molecular Formula
    C20H24O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C[C@@H]1C(C)(C)C=CC([C@](CO2)1[C@@](CC[C@@](C3)([H])[C@@H](C)C4=O)([H])[C@]43C2=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

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